Cheng Hui

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姓  名: 程辉 性  别: 男
职  务: 职  称: 副研究员
学  历: 博士 通讯地址: 天津市和平区南京路288号
电  话: 022-23909396 邮政编码: 300020
传  真: 电子邮件: chenghui@ihcams.ac.cn

教育:
2007.09 – 2012.12 博士研究生,中国医学科学院&北京协和医学院 血液病医院(血液学研究所)内科学
2003.09 – 2007.06 本科,浙江大学,生命科学学院,生物信息学

工作:
2015.09 – 至今 副研究员,中国医学科学院&北京协和医学院 血液病医院(血液学研究所)
2016.07 – 2017.03 访问学者,以色列魏兹曼研究所
2013.09 – 2015.08 科研助理,中国医学科学院&北京协和医学院 血液病医院(血液学研究所)

研究领域:
主要从事造血干/祖细胞(HSC)及造血微环境(Niche)相关研究。以白血病为模型,研究正常造血干/祖细胞及其微环境的生物学功能;以正常造血干/祖细胞为参照,研究白血病细胞的选择性清除;以iPS为手段,研究造血干/祖细胞与白血病细胞的重编程。阐明了白血病状态下造血干/祖细胞的动力学变化以及分子机制;证明了原代白血病细胞能有效重编程为iPS细胞。近5年来以第一(通讯)或合作作者在Blood, Leukemia等SCI刊物上发表文章20余篇。

获奖和荣誉:
2017年天津市“131”创新型人才培养工程第三层次
2016年天津市创新人才推进计划青年科技优秀人才
2016年协和新星
2016年教育部自然科学奖二等奖:造血干细胞病理状态下调控机制及关键分子靶点(第6完成人)
2015年天津市自然科学奖一等奖:造血干细胞病理状态下调控机制及关键分子靶点(第10完成人)
2014年北京协和医学院优秀博士论文
2011年第13届美洲华人生物学学会蒋观铭奖学金;
2011年德国第二届成体干细胞衰老研讨会旅行奖

承担课题:
1. Egr3调控造血干细胞功能的机制研究 (2014年国家自然科学基金青年科学基金项目)。81400077(负责人),23万
2. 造血干细胞发育、维持与再生的调控机制 (2016年国家重点研发计划,干细胞及转化研究)。2016ZY05002341(主要参与人),100万
3. 中胚层来源组织干细胞的谱系层级、发育调控及制备策略(2017年国家重点研发计划,干细胞及转化研究)2017YFA0103400 (主要参与人),200万
4. 急性髓系白血病细胞干性的调控机制及干预策略(2015年国家自然科学基金重点项目)。81430004 (主要参与人),100万
5. 白血病重塑微环境及其对正常造血的影响机制(2017年国家自然科学基金重点项目)81730006(主要参与人),200万
6. 细胞异质性的表观遗传调控机理 (医科院创新工程),子课题负责人,160万

代表论著
1. Y. Gong, M. Zhao, W. Yang, A. Gao, X. Yin, L. Hu, X. Wang, J. Xu, S. Hao, T. Cheng, and H. Cheng, ‘Megakaryocyte-Derived Excessive Tgfbeta1 Inhibits Proliferation of Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia’, Exp Hematol (2018).
2. H. Cheng, Y. Liu, Q. Jia, S. Ma, W. Yuan, H. Jia, and T. Cheng, ‘Novel Regulators in Hematopoietic Stem Cells Can Be Revealed by a Functional Approach under Leukemic Condition’, Leukemia, 30 (2016), 2074-77.
3. H. Cheng, and T. Cheng, ”Waterloo’: When Normal Blood Cells Meet Leukemia’, Curr Opin Hematol, 23 (2016), 304-10.
4. H. Cheng, S. Hao, Y. Liu, Y. Pang, S. Ma, F. Dong, J. Xu, G. Zheng, S. Li, W. Yuan, and T. Cheng, ‘Leukemic Marrow Infiltration Reveals a Novel Role for Egr3 as a Potent Inhibitor of Normal Hematopoietic Stem Cell Proliferation’, Blood, 126 (2015), 1302-13.
5. Y. Liu#, H. Cheng#, S. Gao, X. Lu, F. He, L. Hu, D. Hou, Z. Zou, Y. Li, H. Zhang, J. Xu, L. Kang, Q. Wang, W. Yuan, and T. Cheng, ‘Reprogramming of Mll-Af9 Leukemia Cells into Pluripotent Stem Cells’, Leukemia, 28 (2014), 1071-80.
6. H. Cheng, P. H. Liang, and T. Cheng, ‘Mouse Hematopoietic Stem Cell Transplantation’, Methods Mol Biol, 976 (2013), 25-35.
7. R. Li, Y. Wang, H. Cheng, G. Liu, T. Cheng, Y. Liu, and L. Liu, ‘System Modeling Reveals the Molecular Mechanisms of Hsc Cell Cycle Alteration Mediated by Maff and Egr3 under Leukemia’, BMC Syst Biol, 11 (2017), 91.
8. L. Wang, H. Yu, H. Cheng, K. He, Z. Fang, L. Ge, T. Cheng, and Y. Jin, ‘Deletion of Stk40 Impairs Definitive Erythropoiesis in the Mouse Fetal Liver’, Cell Death Dis, 8 (2017), e2722.
9. Y. Fang, Y. Yang, C. Hua, S. Xu, M. Zhou, H. Guo, N. Wang, X. Zhao, L. Huang, F. Yu, H. Cheng, M. L. Wang, L. Meng, T. Cheng, W. Yuan, D. Ma, and J. Zhou, ‘Rictor Has a Pivotal Role in Maintaining Quiescence as Well as Stemness of Leukemia Stem Cells in Mll-Driven Leukemia’, Leukemia, 31 (2017), 414-22.
10. H. Guo, Y. Chu, L. Wang, X. Chen, Y. Chen, H. Cheng, L. Zhang, Y. Zhou, F. C. Yang, T. Cheng, M. Xu, X. Zhang, J. Zhou, and W. Yuan, ‘Pbx3 Is Essential for Leukemia Stem Cell Maintenance in Mll-Rearranged Leukemia’, Int J Cancer, 141 (2017), 324-35.
11. T. Hu, C. Li, L. Wang, Y. Zhang, L. Peng, H. Cheng, Y. Chu, W. Wang, H. Ema, Y. Gao, Z. Ju, Z. Yang, X. Wang, T. Cheng, and W. Yuan, ‘Pdk1 Plays a Vital Role on Hematopoietic Stem Cell Function’, Sci Rep, 7 (2017), 4943.
12. H. Zhang, H. Cheng, Y. Wang, Y. Zheng, Y. Liu, K. Liu, J. Xu, S. Hao, W. Yuan, T. Zhao, and T. Cheng, ‘Reprogramming of Notch1-Induced Acute Lymphoblastic Leukemia Cells into Pluripotent Stem Cells in Mice’, Blood Cancer J, 6 (2016), e444.
13. Y. Wang, A. Gao, H. Zhao, P. Lu, H. Cheng, F. Dong, Y. Gong, S. Ma, Y. Zheng, H. Zhang, Y. Zhang, J. Xu, X. Zhu, W. Yuan, X. Zhang, S. Hao, and T. Cheng, ‘Leukemia Cell Infiltration Causes Defective Erythropoiesis Partially through Mip-1alpha/Ccl3’, Leukemia, 30 (2016), 1897-908.
14. Y. Zheng, H. Zhang, Y. Wang, X. Li, P. Lu, F. Dong, Y. Pang, S. Ma, H. Cheng, S. Hao, F. Tang, W. Yuan, X. Zhang, and T. Cheng, ‘Loss of Dnmt3b Accelerates Mll-Af9 Leukemia Progression’, Leukemia, 30 (2016), 2373-84.
15. F. Dong, S. Hao, S. Ma, H. Cheng, Y. Wang, W. Zhou, W. Yuan, H. Ema, and T. Cheng, ‘A Novel Lymphoid Progenitor Cell Population (Lsk(Low)) Is Restricted by P18(Ink4c)’, Exp Hematol, 44 (2016), 874-85 e5.
16. R. Li, H. Cheng, T. Cheng, and L. Liu, ‘Digitalization of a Non-Irradiated Acute Myeloid Leukemia Model’, BMC Syst Biol, 10 Suppl 3 (2016), 64.
17. Y. Gao, P. Yang, H. Shen, H. Yu, X. Song, L. Zhang, P. Zhang, H. Cheng, Z. Xie, S. Hao, F. Dong, S. Ma, Q. Ji, P. Bartlow, Y. Ding, L. Wang, H. Liu, Y. Li, W. Miao, W. Yuan, Y. Yuan, T. Cheng, and X. Q. Xie, ‘Small-Molecule Inhibitors Targeting Ink4 Protein P18(Ink4c) Enhance Ex Vivo Expansion of Haematopoietic Stem Cells’, Nat Commun, 6 (2015), 6328.
18. T. Hu, C. Li, Y. Zhang, L. Wang, L. Peng, H. Cheng, W. Wang, Y. Chu, M. Xu, T. Cheng, and W. Yuan, ‘Phosphoinositide-Dependent Kinase 1 Regulates Leukemia Stem Cell Maintenance in Mll-Af9-Induced Murine Acute Myeloid Leukemia’, Biochem Biophys Res Commun, 459 (2015), 692-8.
19. C. Jiang, X. Hu, L. Wang, H. Cheng, Y. Lin, Y. Pang, W. Yuan, T. Cheng, and J. Wang, ‘Excessive Proliferation and Impaired Function of Primitive Hematopoietic Cells in Bone Marrow Due to Senescence Post Chemotherapy in a T Cell Acute Lymphoblastic Leukemia Model’, J Transl Med, 13 (2015), 234.
20. Y. Wang, C. Chen, F. Dong, S. Ma, J. Xu, Y. Gong, H. Cheng, Y. Zhou, T. Cheng, and S. Hao, ‘Nk Cells Play a Significant Role in Immunosurveillance at the Early Stage of Mll-Af9 Acute Myeloid Leukemia Via Cd226/Cd155 Interactions’, Sci China Life Sci, 58 (2015), 1288-98.
21. Y. Zhao, J. Zhou, D. Liu, F. Dong, H. Cheng, W. Wang, Y. Pang, Y. Wang, X. Mu, Y. Ni, Z. Li, H. Xu, S. Hao, X. Wang, S. Ma, Q. F. Wang, G. Xiao, W. Yuan, B. Liu, and T. Cheng, ‘Atf4 Plays a Pivotal Role in the Development of Functional Hematopoietic Stem Cells in Mouse Fetal Liver’, Blood, 126 (2015), 2383-91.
22. L. Hu, H. Cheng, Y. Gao, M. Shi, Y. Liu, Z. Hu, J. Xu, L. Qiu, W. Yuan, A. Y. Leung, Y. G. Yang, and T. Cheng, ‘Antioxidant N-Acetyl-L-Cysteine Increases Engraftment of Human Hematopoietic Stem Cells in Immune-Deficient Mice’, Blood, 124 (2014), e45-8.
23. C. Hua, H. Guo, J. Bu, M. Zhou, H. Cheng, F. He, J. Wang, X. Wang, Y. Zhang, Q. Wang, J. Zhou, T. Cheng, M. Xu, and W. Yuan, ‘Rictor/Mammalian Target of Rapamycin 2 Regulates the Development of Notch1 Induced Murine T-Cell Acute Lymphoblastic Leukemia Via Forkhead Box O3’, Exp Hematol, 42 (2014), 1031-40 e1-4.
24. Y. Lin, X. Hu, H. Cheng, Y. Pang, L. Wang, L. Zou, S. Xu, X. Zhuang, C. Jiang, W. Yuan, T. Cheng, and J. Wang, ‘Graft-Versus-Host Disease Causes Broad Suppression of Hematopoietic Primitive Cells and Blocks Megakaryocyte Differentiation in a Murine Model’, Biol Blood Marrow Transplant, 20 (2014), 1290-300.
25. S. Ma, Y. Shi, Y. Pang, F. Dong, H. Cheng, S. Hao, J. Xu, X. Zhu, W. Yuan, T. Cheng, and G. Zheng, ‘Notch1-Induced T Cell Leukemia Can Be Potentiated by Microenvironmental Cues in the Spleen’, J Hematol Oncol, 7 (2014), 71.
26. X. Zhu, F. He, H. Zeng, S. Ling, A. Chen, Y. Wang, X. Yan, W. Wei, Y. Pang, H. Cheng, C. Hua, Y. Zhang, X. Yang, X. Lu, L. Cao, L. Hao, L. Dong, W. Zou, J. Wu, X. Li, S. Zheng, J. Yan, J. Zhou, L. Zhang, S. Mi, X. Wang, Y. Zou, Y. Chen, Z. Geng, J. Wang, X. Liu, W. Yuan, G. Huang, T. Cheng, and Q. F. Wang, ‘Identification of Functional Cooperative Mutations of Setd2 in Human Acute Leukemia’, Nat Genet, 46 (2014), 287-93.
27. Y. Zhang, F. Dong, N. Zhang, H. Cheng, Y. Pang, X. Wang, J. Xu, X. Ding, T. Cheng, J. Gu, and W. Yuan, ‘Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice’, PLoS One, 8 (2013), e69913.
28. Y. Zhang, C. Hua, H. Cheng, W. Wang, S. Hao, J. Xu, X. Wang, Y. Gao, X. Zhu, T. Cheng, and W. Yuan, ‘Distinct Sensitivity of Cd8+ Cd4- and Cd8+ Cd4+ Leukemic Cell Subpopulations to Cyclophosphamide and Rapamycin in Notch1-Induced T-All Mouse Model’, Leuk Res, 37 (2013), 1592-601.

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About Us

Our team member is young and energetic.Our laboratory primarily focuses on both genetic and epigenetic mechanisms in hematopoietic stem and progenitor cells, with each project guided by methods intended to elucidate basic principles as well as practical solutions. Through broadly collaborative approaches, We also committed to training hematologists and stem cell biologists and to building strong and competitive hematology and stem cell research programs that will ultimately benefit the patients.