Hu Linping

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中国医学科学院,血液病医院(血液学研究所)实验血液学国家重点实验室,助理研究员。中国细胞生物学会会员,中国生理学会会员。2010年6月毕业于中国医学科学院 北京协和医学院,获得细胞生物学硕士学位(导师:程涛 教授)。2016年5月攻读中国医学科学院 北京协和医学院,医学内科学博士研究生(导师:程涛 教授)。2010年7月至2013年12月,中国医学科学院,血液病医院(血液学研究所)实验血液学国家重点实验室,程涛教授课题组,研究实习员。2010年9月赴瑞典卡罗林斯卡医学院肿瘤研究中心Anders Zetterberg教授实验室参与课题研究。2015年5月赴美国罗马琳达大学医学中心,张孝兵教授实验室参与课题研究。2013年12月至今,中国医学科学院,血液病医院(血液学研究所)实验血液学国家重点实验室,程涛教授课题组,助理研究员。主要从事造血调控和造血干细胞移植相关性研究,证明了降低氧化代谢物可以提高造血干细胞移植率。此外,对肿瘤和白血病的基因诊断,尤其是定量多色荧光原位杂交(QM-FISH)进行了深入的研究,研发出一系列创新性的FISH基因诊断产品,用于诊断多种恶性血液疾病。荣获国家授权发明专利6项。主持国家自然基金青年基金1项,协和青年基金1项,参与国家重大科学研究计划(973)课题,科技部中瑞国际合作,基金委中以国际合作,基金委重点项目,医科学院重大协同创新项目。相关研究成果发表在Blood、Leukemia等高水平杂志上,共发表研究论文25篇,SCI收录11篇。2012年荣获美国血液学年会摘要成就奖和美国卡昂青年研究者奖。2016年荣获教育部自然科学二等奖。

邮箱: hulinping@ihcams.ac.cn

Education
2016-Present Doctor’s Degree in Medical Internal Medicine. Peking Union Medical College, Beijing, China. Research subject: Effects of Niche Factors on engraftment of human hematopoietic stem cells in immunodeficient mice.
2007-2010 Master’s Degree in Cell Biology. Peking Union Medical College, Beijing, China. Thesis: Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice.
2002-2007 Bachelor’s Degree in Clinical Medicine. ChangZhi Medical College, ShanXi, China.

Postgraduate Training
05-08/2015 Volunteer, Division of Regenerative Medicine, Loma Linda University, USA.
09-11/2010 Visiting scholar, Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm, Sweden.

Positions and Employment
12/2013-Present Assistant research fellow, Institute of Hematology & Hospital of Blood Diseases Chinese Academy of Medical Sciences & Peking Union Medical College. Tianjin, China. Research field is hematopoitic stem cells.
08/2010-12/2013 Research Intern, Institute of Hematology & Hospital of Blood Diseases Chinese Academy of Medical Sciences & Peking Union Medical College. Tianjin, China. Research field is hematopoitic stem cells.

Awards and Honors
02/2016 Excellent achievement award for scientific research in Colleges and Universities,Two prize for Natural Science
10/2012 The American Society of Hematology (ASH) Abstract Achievement Award
10/2012 CAHON Young Investigator Award

Research Funding
The National Science Foundation of China (81400150) (P.I. Linping Hu)
PUMC Youth Fund and the Fundamental Research Funds for the Central Universities (3332016090) (P.I. Linping Hu)

Publications
1. Gong, Y.; Zhao, M.; Yang, W.; Gao, A.; Yin, X.; Hu, L.; Wang, X.; Xu, J.; Hao, S.; Cheng, T.; Cheng, H., Megakaryocyte-derived excessive transforming growth factor beta1 inhibits proliferation of normal hematopoietic stem cells in acute myeloid leukemia. Exp Hematol 2018, 60, 40-46 e2.
2. Hu, L.; Yin, X.; Sun, J.; Zetterberg, A.; Miao, W.; Cheng, T., A molecular pathology method for sequential fluorescence in situ hybridization for multi-gene analysis at the single-cell level. Oncotarget 2017, 8 (31), 50534-50541.
3. Li, F.; Hu, L.; Xu, Y.; Li, Z.; Yi, S.; Gu, Z.; Li, C.; Hao, M.; Ru, K.; Zhan, F.; Zetterberg, A.; Yuan, W.; Cheng, T.; Qiu, L., Identification of characteristic and prognostic values of chromosome 1p abnormality by multi-gene fluorescence in situ hybridization in multiple myeloma. Leukemia 2016, 30 (5), 1197-201.
4. Zhang, J. P.; Li, X. L.; Neises, A.; Chen, W.; Hu, L. P.; Ji, G. Z.; Yu, J. Y.; Xu, J.; Yuan, W. P.; Cheng, T.; Zhang, X. B., Different Effects of sgRNA Length on CRISPR-mediated Gene Knockout Efficiency. Sci Rep 2016, 6, 28566.
5. Li, J.; Su, W.; Zhang, S.; Hu, Y.; Liu, J.; Zhang, X.; Bai, J.; Yuan, W.; Hu, L.; Cheng, T.; Zetterberg, A.; Lei, Z.; Zhang, J., Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybridization impact on prognosis in breast cancer. Cancer Sci 2015, 106 (5), 642-9.
6. Hu, L.; Cheng, H.; Gao, Y.; Shi, M.; Liu, Y.; Hu, Z.; Xu, J.; Qiu, L.; Yuan, W.; Leung, A. Y.; Yang, Y. G.; Cheng, T., Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood 2014, 124 (20), e45-8.
7. Hu, L.; Ru, K.; Zhang, L.; Huang, Y.; Zhu, X.; Liu, H.; Zetterberg, A.; Cheng, T.; Miao, W., Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine. Biomark Res 2014, 2 (1), 3.
8. Li, C.; Bai, J.; Hao, X.; Zhang, S.; Hu, Y.; Zhang, X.; Yuan, W.; Hu, L.; Cheng, T.; Zetterberg, A.; Lee, M. H.; Zhang, J., Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients. Cell Cycle 2014, 13 (8), 1299-305.
9. Liu, Y.; Cheng, H.; Gao, S.; Lu, X.; He, F.; Hu, L.; Hou, D.; Zou, Z.; Li, Y.; Zhang, H.; Xu, J.; Kang, L.; Wang, Q.; Yuan, W.; Gao, S.; Cheng, T., Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia 2014, 28 (5), 1071-80.
10. Zhang, S.; Shao, Y.; Hou, G.; Bai, J.; Yuan, W.; Hu, L.; Cheng, T.; Zetterberg, A.; Zhang, J., QM-FISH analysis of the genes involved in the G1/S checkpoint signaling pathway in triple-negative breast cancer. Tumour Biol 2014, 35 (3), 1847-54.
11. Miao, W.; Xufeng, R.; Park, M. R.; Gu, H.; Hu, L.; Kang, J. W.; Ma, S.; Liang, P. H.; Li, Y.; Cheng, H.; Yu, H.; Epperly, M.; Greenberger, J.; Cheng, T., Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice. Mol Ther 2013, 21 (2), 423-32.

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About Us

Our team member is young and energetic.Our laboratory primarily focuses on both genetic and epigenetic mechanisms in hematopoietic stem and progenitor cells, with each project guided by methods intended to elucidate basic principles as well as practical solutions. Through broadly collaborative approaches, We also committed to training hematologists and stem cell biologists and to building strong and competitive hematology and stem cell research programs that will ultimately benefit the patients.