Lu Shihong

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卢士红工作简介:

职称:副主任技师
目前主要从事骨髓微环境间充质干细胞生物学功能的研究工作。曾从事人骨髓造血干细胞与间充质干细胞相互作用的研究工作,建立了体外人骨髓间充质干细胞与造血干细胞共培养体系;熟练操作实验动物的体内、体外实验:如建立小鼠骨髓造血损伤模型,给造血衰竭小鼠体内共移植造血干细胞和间充质干细胞;对移植细胞的归巢、放射损伤小鼠造血重建进行了研究;体外造血干细胞体外集落形成及长期培养起始细胞集落形成实验、巨核细胞集落形成实验等;熟练操作小鼠体内、体外血管生成的相关实验;诱导细胞横向分化实验:如诱导造血干细胞向巨核细胞分化、间充质干细胞向成脂、成骨、成软骨、成内皮、成神经细胞分化等实验;熟练掌握细胞增殖、粘附、趋化、呼吸爆发、周期、凋亡、自噬和衰老方面的实验。对PKC信号通路、TPK信号通路与细胞呼吸爆发功能之间关系进行过研究,NF-kB信号通路与细胞自噬、衰老作用之间关系进行过研究。曾参与过多项基金项目,如国家自然基金重点项目《骨髓衰竭的病理机制及干预策略的基础研究》、国家863项目《干细胞定向分化为血管和神经的研究及临床应用》、863项目《治疗血液肿瘤的脐带间充质干细胞和巨核细胞注射液的研制》、科技部国际合作重点项目《血液血管干细胞生物学特性及其生长调控》、973项目《组织干细胞可塑性的研究》、攀登计划《造血组织干细胞工程的基础研究》、CMB基金《Stem Cell Biology , Engineering》等课题。发表论文50余篇。
获奖情况:
获得国家科技进步奖二等奖一项;教育部自然科学二等奖一项;天津市自然科学二等奖一项;高等学校科学技术奖科技进步奖二等奖一项。
获得已授权专利1项:
专利号:200910068510.1, 一种培养间充质干细胞的低血清浓度完全培养基和利用该培养基培养间充质干细胞的方法。
近期发表SCI论文:
Shihong Lu,1 Meili Ge,1 Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng,Donglin Yang, Jun Shi, Fang Chen, and Zhongchao Han. CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF-κB in the bone marrow failure of acquired aplastic anemia. Stem Cell Res Ther. 2017 ;8(1):178. doi: 10.1186/s13287-017-0620-4.
You Y, Huo J, Lu S, Shao Y, Ge M, Shi J, Li X, Huang J, Huang Z, Zhang J, Wang M, Nie N, Zheng Y. The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes. Leuk Lymphoma. 2017 Jul 21:1-8. doi: 10.1080/10428194.2017.1352092.
Junhong Li, Meili Ge, Shihong Lu, Jun Shi, Xingxin Li, Min Wang, Jinbo Huang, Yingqi Shao, Zhendong Huang, Jing Zhang, Neng Nie, Yizhou Zheng. Pro-inflammatory effects of the Th1 chemokine CXCL10 in acquired aplastic anaemia. Cytokine. 2017 ;94:45-51. doi: 10.1016/j.cyto.2017.04.010.
Li JJ, Ma FX, Wang YW, Chen F, Lu SH, Chi Y, Du WJ, Song BQ, Hu LD, Chen H, Han ZC. Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells. Stem Cells Dev. 2017;15;26(12):912-931. doi: 10.1089/scd.2016.0324.
Huang J, Ge M, Lu S, Shi J, Yu W, Li X, Wang M, Zhang J, Feng S, Dong S, Cheng X, Zheng Y. Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance. PLoS One. 2016;11(3): e0149586.
Yu W, Ge M, Lu S, Shi J, Feng S, Li X, Zhang J, Wang M, Huang J, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Decreased expression of vitamin D receptor may contribute to the hyperimmune status of patients with acquired aplastic anemia. Eur J Haematol. 2016 ;96(5):507-16.
Huang J, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Yu W, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Mutations of ASXL1 and TET2 in aplastic anemia. Haematologica. 2015;100(5):e172-5.
Yu W, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Huang J, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Anti-inflammatory effects of interleukin-35 in acquired aplastic anemia. Cytokine. 2015 ;76(2):409-16.
Ge M, Zheng Y, Li X, Lu S, Li H, Chen F, Shao Y, Shi J, Feng S. Differential expression profile of Th1/Th17/Th2-related chemokines and their receptors in patients with acquired bone marrow failure syndromes. Hum Immunol. 74(2): 176-80.2013.
Shi J, Ge M, Lu S, Li X, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia. Blood. 2012; 120(8):1624-32.
Jianping Li1, Shihong Lu1, Shaoguang Yang, Wen Xing, Jianming Feng, Wenqian Li, Qinjun Zhao, Hao Wu, Meili Ge, Fengxia Ma, Hui Zhao, Bin Liu, Lei Zhang, Yizhou Zheng, Zhong Chao Han. Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4+ T cells in aplastic anemia. Results in Immunology 2 (2012) 142–147.
Lei Zhang1, Shi Hong Lu1, Li Li, Tao YG, Yong Ling Wan, Senga H, Renchi Yang, Zhong Chao Han. Batroxobin mobilizes circulating endothelial progenitor cells in patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2011 ;17(1):75-9.
Wu KH, Mo XM, Zhou B, Lu SH, Yang SG, Liu YL, Han ZC. Cardiac potential of stem cells from whole human umbilical cord tissue. J Cell Biochem. 2009;107(5):926-32.
Xu JH, Lu SH, Tao J, Zhou ZP, Chen Z, Huang Y, Yang RC. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. J Clin Immunol. 2008 ;28(3):214-219.
Wu KH, Zhou B, Lu SH, Feng B,Yang SG, Du WT, Gu DS,Han ZC, Liu YL. In Vitro and in Vivo Differentiation of Human Umbilical Cord Derived Stem Cells Into Endothelial Cells. J Cell Biochem , 2007,100(3):608-616.
Fan CG, Tang FW, Lu SH, Liu HY, Zhao ZM, Liu B, Han ZB, Han ZC. Characterization and neural differentiation of fetal lung mesenchymal stem cells. Cell Transplant. 2005, 14(5):311-21.
Liu YJ, Lu SH, Han ZC. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood, 2004, 103(12):4449-4456.
Jing Zhang1 , Shi Hong Lu1 , Yong Jun Liu , Yi Feng , Zhong Chao Han . Platelet factor enhances the adhesion of normal and leukemic Hematopoietic stem/progenitor cells to endothelial cells. Leukemia Research. 2004;28(6):631-638.
Liu YJ, Lu SH, Han ZC. Signal transduction of chemokine platelet factor 4 in human erythroleukemia cells. Int J Hematol. 2002;75:401-406.
以第一作者发表中文核心期刊文章:
卢士红, 葛美丽, 郑以州, 杨少光, 陈芳, 尤亚红, 韩忠朝. 再生障碍性贫血患者骨髓CD106+间充质干细胞对其骨髓血管衰竭的作用. 中国医学科学院学报。2018,Vol.40(2):178-186。doi.org/10.3881/j.issn.1000-503X.2018.02.007
卢士红,刘斌,邢文,张磊,张翔宇,任倩,刘鹏霞,庞天翔,杨仁池,韩忠朝。 促血液血管生成素促进放射损伤小鼠的造血重建。中国生物工程杂志,2008,28(9)14-18。
卢士红,刘拥军,杨仁池,韩忠朝等。促血液血管细胞生成素对胎儿骨髓造血和内皮干细胞的作用。中国科技论文在线,编号为:200611-409。
卢士红,刘拥军,闫凤英,杨仁池,任倩,杨晨,张磊,任贺,韩忠朝。血液血管细胞生成素对胎儿骨髓造血和内皮干细胞作用的研究。生物医学工程与临床,2005,9(6).353-357。
卢士红,冯义,杨仁池,刘拥军,翟琼莉,张志华,韩忠朝。 血小板第四因子对脐血CD34+细胞粘附功能的研究。中华血液学杂志,2003,24(9): 467-9。
卢士红,刘拥军,陆敏,冯义,李文影,蔡英林,韩忠朝。 PF4对造血干祖细胞系KG1a总粘附性、粘附分子表达及细胞骨架蛋白聚合的作用。中国医学科学院学报,2002,24(1):25-29。
卢士红,刘拥军,马月霞,杨琳,韩忠朝。血小板第4因子(PF4)对中性粒细胞粘附性与呼吸爆发的调节作用。中国医学科学院学报,2001,23:490-494。
卢士红,姜新。荧光分光光度法测定中性粒细胞H2O2水平及意义。中华血液学杂志,1996.17(5).265-266。

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About Us

Our team member is young and energetic.Our laboratory primarily focuses on both genetic and epigenetic mechanisms in hematopoietic stem and progenitor cells, with each project guided by methods intended to elucidate basic principles as well as practical solutions. Through broadly collaborative approaches, We also committed to training hematologists and stem cell biologists and to building strong and competitive hematology and stem cell research programs that will ultimately benefit the patients.