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  1. Zhan Z, Song L, Zhang W, Gu H, Cheng H, Zhang Y, Yang Y, Ji G, Feng H*, Cheng T*, Li Y*. Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability. Cell Death Dis. 2019 Mar 20;10(4):271.
  2. Shen J, Lyu C, Zhu Y, Feng Z, Zhang S, Hoyle DL, Ji G, Brodsky RA, Cheng T*, Wang ZZ*. Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling. J Cell Physiol. 2019 Feb 10. doi: 10.1002/jcp.28272.
  3. Zhang J, Zhang Y, Zhang M, Liu C, Liu X, Yin J, Wu P, Cheng X, Yang W, Zhang L, Guo Y, Zou Y, Chen Y, Cao Y, Cheng T*, Zhu X*. FLT3 pathway is a potential therapeutic target for PRC2 mutated T cell acute lymphoblastic leukemia. Blood. 2018 Dec 6;132(23):2520-2524.
  4. Li XL, Li GH, Fu J, Fu YW, Zhang L, Chen W, Arakaki C, Zhang JP, Wen W, Zhao M, Chen WV, Botimer GD, Baylink D, Aranda L, Choi H, Bechar R, Talbot P, Sun CK*, Cheng T*, Zhang XB*. Highly efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression. Nucleic Acids Res.  2018 Nov 2;46(19):10195-10215.
  5. Wen W, Cheng X, Fu Y, Meng F, Zhang JP, Zhang L, Li XL, Yang Z, Xu J, Zhang F, Botimer GD, Yuan W, Sun C, Cheng T*, Zhang XB*. High-Level Precise Knockin of iPSCs by Simultaneous Reprogramming and Genome Editing of Human Peripheral Blood Mononuclear Cells. Stem Cell Reports. 2018 Jun 5;10(6):1821-1834.
  6. Gong Y, Zhao M, Yang W, Gao A, Yin X, Hu L, Wang X, Xu J, Hao S, Cheng T*, Cheng H*. Megakaryocyte-derived excessive TGFβ1 inhibits proliferation of normal hematopoietic stem cells in acute myeloid leukemia. Exp Hematol. 2018 Apr;60:40-46.e2.
  7. Wu D, Luo Y, Guo W, Niu Q, Xue T, Yang F, Sun X, Chen S, Liu Y, Liu J, Sun Z, Zhao C, Huang H, Liao F, Han Z, Zhou D, Yang Y, Xu G, Cheng T*, Feng X*. Lkb1 maintains Treg cell lineage identity. Nat Commun. 2017 Jun 16;8:15876.
  8. Zhang Y, Zhang J, An W, Wan Y, Ma S, Yin J, Li X, Gao J, Yuan W, Guo Y, Engel JD, Shi L*, Cheng T*, Zhu X*. Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation. Nucleic Acids Res. 2017 Jan 25;45(2):657-671.
  9. Wen W, Zhang JP, Chen W, Arakaki C, Li X, Baylink D, Botimer GD, Xu J, Yuan W, Cheng T*, Zhang XB*. Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors. J Vis Exp. 2017 Jan 1;(119). doi: 10.3791/55091.
  10. Zhang JP, Li XL, Li GH, Chen W, Arakaki C, Botimer GD, Baylink D, Zhang L, Wen W, Fu YW, Xu J, Chun N, Yuan W, Cheng T*, Zhang XB*. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.
  11. Zhang H, Cheng H, Wang Y, Zheng Y, Liu Y, Liu K, Xu J, Hao S, Yuan W, Zhao T, Cheng T. Reprogramming of Notch1-induced acute lymphoblastic leukemia cells into pluripotent stem cells in mice. Blood Cancer J. 2016 Jul 8;6(7):e444.
  12. Dong F, Hao S, Ma S, Cheng H, Wang Y, Zhou W, Yuan W, Ema H, Cheng T. A novel lymphoid progenitor cell population (LSKlow) is restricted by p18INK4c. Exp Hematol.  2016 Sep;44(9):874-885.e5.
  13. Wen W, Zhang JP, Xu J, Su RJ, Neises A, Ji GZ, Yuan W, Cheng T*, Zhang XB*. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports. 2016 Jun 14;6(6):873-884.
  14. Cheng H, Liu Y, Jia Q, Ma S, Yuan W, Jia H, Cheng T. Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition. Leukemia. 2016 Oct;30(10):2074-2077.
  15. Zheng Y, Zhang H, Wang Y, Li X, Lu P, Dong F, Pang Y, Ma S, Cheng H, Hao S, Tang F, Yuan W, Zhang X, Cheng T. Loss of Dnmt3b accelerates MLL-AF9 leukemia progression. Leukemia. 2016 Dec;30(12):2373-2384.
  16. Wang Y, Gao A, Zhao H, Lu P, Cheng H, Dong F, Gong Y, Ma S, Zheng Y, Zhang H, Zhang Y, Xu J, Zhu X, Yuan W, Zhang X, Hao S, Cheng T. Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3. Leukemia. 2016 Sep;30(9):1897-908.
  17. Wang Y, Chen C, Dong F, Ma S, Xu J, Gong Y, Cheng H, Zhou Y, Cheng T*, Hao S*.  NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions. SCIENCE CHINA Life Sciences. 2015 Nov 20.
  18. Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W, Pang Y, Wang Y, Mu X, Ni Y, Li Z, Xu H, Hao S, Wang X, Ma S, Wang QF, Xiao G, Yuan W, Liu B*, Cheng T* . ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015 Nov 19;126(21):2383-91.
  19. Lim M, Pang Y, Ma S, Hao S, Shi H, Zheng Y, Hua C, Gu X, Yang F, Yuan W, Cheng T. Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow. Leukemia. 2016 Jan;30(1):154-62.
  20. Cheng H, Hao S, Liu Y, Pang Y, Ma S, Dong F, Xu J, Zheng G, Li S, Yuan W, Cheng T. Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation. Blood. 2015 Sep 10;126(11):1302-13.
  21. Gao Y, Yang P, Shen H, Yu H, Song X, Zhang L, Zhang P, Cheng H, Xie Z, Hao S, Dong F, Ma S, Ji Q, Bartlow P, Ding Y, Wang L, Liu H, Li Y, Cheng H, Miao W, Yuan W, Yuan Y, Cheng T*, Xie XQ*. Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nature Communications. 2015 Feb 18;6:6328.
  22. Hu L, Cheng H, Gao Y, Shi M, Liu Y, Hu Z, Xu J, Qiu L, Yuan W, Leung AY, Yang YG, Cheng T. The antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood. 2014 Nov 13;124(20):e45-8.
  23. Ma S, Shi Y, Pang Y, Dong F, Cheng H, Hao S, Xu J, Zhu X, Yuan W, Cheng T*, Zheng G*. Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen. Journal of Hematology & Oncology. 2014 Nov 4;7(1):71.
  24. Zhang Y, Hu T, Hua C, Gu J, Zhang L, Hao S, Liang H, Wang X, Wang W, Xu J, Liu H, Liu B, Cheng T*, Yuan W*. Rictor is required for early B cell development in bone marrow. PLoS One. 2014 Aug 1;9(8):e103970. doi: 10.1371/journal.pone.0103970.
  25. Lin Y, Hu X, Cheng H, Pang Y, Wang L, Zou L, Xu S, Zhuang X, Jiang C, Yuan W, Cheng T*, Wang J*. Graft-Versus-Host Disease Causes Broad Suppression of Hematopoietic Primitive Cells and Blocks Megakaryocyte Differentiation in a Murine Model. Biology of Blood and Marrow Transplantation. 2014 May 15. pii: S1083-8791(14)00294-8. doi: 10.1016/j.bbmt.2014.05.009.
  26. Chang L, Yuan W, Zeng H, Zhou Q, Wei W, Zhou J, Li M, Wang X, Xu M, Yang F, Yang Y, Cheng T*, Zhu X*. Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients. BMC Medical Genomics. 2014 May 15;7:24. doi: 10.1186/1755-8794-7-24.
  27. Zhu X, He F, Zeng H, Ling S, Chen A, Wang Y, Yan X, Wei W, Pang Y, Cheng H, Hua C, Zhang Y, Yang X, Lu X, Cao L, Hao L, Dong L, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang L, Mi S, Wang X, Zhang L, Zou Y, Chen Y, Geng Z, Wang J, Zhou J, Liu X, Wang J, Yuan W, Huang G*, Cheng T*, Wang QF*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature Genetics. 2014 Mar;46(3):287-93.
  28. Zhang Y, Hua C, Cheng H, Wang W, Hao S, Xu J, Wang X, Gao Y, Zhu X, Cheng T*, Yuan W*. Distinct sensitivity of CD8+CD4- and CD8+CD4+ leukemic cell subpopulations to cyclophosphamide and rapamycin in Notch1- induced T-ALL. Leukemia Research. 2013 Nov;37(11):1592-601.
  29. Liu Y, Cheng H, Gao S, Zou Z, He F, Hu L, Hou D, Lu X, Li Y, Zhang H, Xu J, Kang L, Wang Q, Yuan W, Gao S*,Cheng T*. Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia. 2014 May;28(5):1071-80.
  30. Li Y, Feng H, Gu H, Lewis D, Yuan Y, Zhang L, Yu H, Zhang P, Cheng H, Miao W, Yuan W, Cheng S, Gollin S,Cheng T. The p53-PUMA axis suppresses iPSC generation. Nature Communications 2013 Jul 19;4:2174.
  31. Miao W, Xufeng R, Park MR, Gu H, Hu L, Kang JW, Ma S, Liang PH, Li Y, Cheng H, Yu H, Epperly M, Greenberger J, Cheng T. Hematopoietic Stem Cell Regeneration Enhanced by Ectopic Expression of ROS-detoxifying Enzymes in Transplant Mice. Molecular Therapy. 2013 Feb;21(2):423-32.
  32. Tian C, Zheng G, Cao Z, Li Q, Ju Z, Wang J, Yuan W, Cheng T. Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment. Cell Cycle. 2013 Jan 15;12(2):322-31.

 

 

 

 

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Our team member is young and energetic.Our laboratory primarily focuses on both genetic and epigenetic mechanisms in hematopoietic stem and progenitor cells, with each project guided by methods intended to elucidate basic principles as well as practical solutions. Through broadly collaborative approaches, We also committed to training hematologists and stem cell biologists and to building strong and competitive hematology and stem cell research programs that will ultimately benefit the patients.


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